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In people with chronic gout, compared with febuxostat (80 mg daily), low-quality evidence indicated that allopurinol (100 to 300 mg daily) may not reduce the number of acute gout attacks, and may be less effective in achieving target serum urate levels, without increasing withdrawals due to AEs, or serious adverse event rates.
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One trial judged to be at low risk of bias and of small size (57 participants) was designed to test the hypothesis that there is no difference in pain or the frequency of gout attacks with early versus delayed initiation of allopurinol for an acute attack of gout ().
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Our review found low- to moderate-quality evidence indicating similar effects on withdrawals due to adverse events or serious adverse events when allopurinol 100 to 600 mg daily was compared with placebo, benzbromarone 100 to 200 mg daily or febuxostat 80 mg daily.
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